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Research

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement

NEJM · By Charles W. Francisthe PEPPER Trial Investigators & the Steering Committee of the PEPPER Trial* ·

The Brief

  • A research article titled "Prevention of Venous Thromboembolism after Total Hip or Knee Replacement" was published in the New England Journal of Medicine.
  • It appears in Volume 395, Issue 19, on pages 1896-1910, with an issue date of November 12, 2026.
  • The source material provided is limited to the title, journal details and link, so study design, sample and results are not reported here.

Why it matters

Venous thromboembolism is a recognised complication after hip and knee replacement, so a high-profile NEJM study on its prevention is relevant to surgeons, hospitals and guideline authors.

Who’s affected

  • orthopaedic surgeons and hospital teams
  • patients considering or recovering from hip or knee replacement
  • #venous thromboembolism
  • #hip replacement
  • #knee replacement
  • #orthopaedics
  • #thrombosis prevention
  • #clinical medicine

New England Journal of Medicine, Volume 395, Issue 19 , Page 1896-1910, November 12, 2026.

Timeline

  1. Article published on NEJM website

  2. nejm.org

    Prevention of Venous Thromboembolism after Total Hip or Knee Replacement

  3. Article appears in NEJM Volume 395, Issue 19

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