Research
Vagus-Hepatic-Creatine axis modulates manic-like behaviors via hippocampal MMP19 upregulation in bipolar disorder
Nature · By Jingyi Yang ·
The Brief
- A research article titled 'Vagus-Hepatic-Creatine axis modulates manic-like behaviors via hippocampal MMP19 upregulation in bipolar disorder' was published online in Molecular Psychiatry on 13 November 2026.
- The title reports that a vagus-hepatic-creatine axis modulates manic-like behaviours in a bipolar disorder model.
- The title links this axis to hippocampal upregulation of MMP19.
Why it matters
The study proposes a body-to-brain pathway linking the liver, creatine metabolism and the vagus nerve to manic-like behaviour, which could point to new research targets for bipolar disorder. Only the title and publication metadata were available, so the strength of the evidence and any translation to patients are unknown.
Who’s affected
- researchers in bipolar disorder and neuropsychiatry
- #bipolar-disorder
- #mania
- #vagus-nerve
- #creatine
- #mmp19
Molecular Psychiatry, Published online: 13 November 2026; doi:10.1038/s41380-026-03938-0 Vagus-Hepatic-Creatine axis modulates manic-like behaviors via hippocampal MMP19 upregulation in bipolar disorder
Timeline
Published online in Molecular Psychiatry
nature.com
Vagus-Hepatic-Creatine axis modulates manic-like behaviors via hippocampal MMP19 upregulation in bipolar disorder