Research2 sources

The blood-brain barrier imports diverse neuroprotective proteins through pathways impaired early in Alzheimer’s disease models

Cell · By Haoyue Zhou, Jason C. Maynard, Alexander J. Pennacchio, Amanda Apolonio, Xi Liu, Lei Yao, Mina Negahban, Zimo Zhang, Bella Ding, Jane Oberhauser, Xinlan Wen, Myung Jin Yang, Fionna Huang, Yuichi Chayama, Sahith Doddipalli, Mylinh Bernardi, Lane Domke, Iris Lo, Jeffrey Simms, Andrew Pan, Sining Du, Ning-Sum To, Pui Shuen Wong, Duc Duong, Eddie Fox, Nicholas T. Seyfried, Tom H. Cheung, Tara E. Tracy, Alma L. Burlingame & Andrew C. Yang · 20h ago

The Brief · written from 2 sources

A study reports that the blood-brain barrier imports diverse plasma proteins into specific brain cell types via receptor-mediated transport.
The import process is dysregulated early in Alzheimer's disease models.
Restoring one diminished liver-derived protein is described in the cell.com summary as a focus of the work.

Why it matters

The findings suggest that impaired protein transport across the blood-brain barrier may be an early feature of Alzheimer's disease models, pointing to transport pathways as possible therapeutic targets.

Who’s affected

neuroscientists studying Alzheimer's disease
researchers working on blood-brain barrier drug delivery

#blood-brain barrier
#alzheimer's disease
#neuroprotection
#receptor-mediated transport
#proteomics

Bioorthogonal proteomics reveals that the blood-brain barrier (BBB) imports diverse plasma proteins to specific brain cell types through receptor-mediated transport, a process dysregulated early in an Alzheimer’s model. Restoring one diminished protein, liver-derived…

Read the full story at cell.com ↗