Research2 sources
Study Rewrites The Rules of The Blood-Brain Barrier, Including Proteins That May Be Involved in Alzheimer's
ScienceAlert · By Jess Cockerill ·
The Brief · written from 2 sources
- A study reports that the blood-brain barrier imports diverse plasma proteins into specific brain cell types via receptor-mediated transport.
- The import process is dysregulated early in Alzheimer's disease models.
- Restoring one diminished liver-derived protein is described in the cell.com summary as a focus of the work.
Why it matters
The findings suggest that impaired protein transport across the blood-brain barrier may be an early feature of Alzheimer's disease models, pointing to transport pathways as possible therapeutic targets.
Who’s affected
- neuroscientists studying Alzheimer's disease
- researchers working on blood-brain barrier drug delivery
- #blood-brain barrier
- #alzheimer's disease
- #neuroprotection
- #receptor-mediated transport
- #proteomics
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Timeline
Study published in Cell and reported by ScienceAlert
cell.com
The blood-brain barrier imports diverse neuroprotective proteins through pathways impaired early in Alzheimer’s disease models
ScienceAlert
Study Rewrites The Rules of The Blood-Brain Barrier, Including Proteins That May Be Involved in Alzheimer's