Spatiotemporal dynamic evolution of the tumor microenvironment during neoadjuvant immunotherapy for bladder cancer
Cell Reports Medicine · By Jiao Hu, Yifan Liu, Minfeng Chen, Jiantu Ou, Tongchen He, Jinhui Liu, Minghui Hu, Bohan Zhou, Huihuang Li, Luzhe Yan, Jiatong Xiao, Zhenyu Nie, Zhiyong Cai, Peihua Liu, Dingshan Deng, Yunbo He, Benyi Fan, Zhenyu Ou, Ruizhe Wang, Guanghui Gong, Xiao Guan, Shiyu Tong, Yangle Li, Wei He, Zefu Liu, Yuanqing Dai, Bolong Liu, Xiaogen Kuang, Tao Guo, Lunquan Sun, Xiaohua Yao, Junhao Yu, Hengyun Wang, Jinbo Chen & Xiongbing Zu ·
Hu et al. map phenotypic evolution of the bladder cancer microenvironment during neoadjuvant immunotherapy. Treatment drives divergent tumor cell fates, establishes an immunotherapy-induced tumor-myeloid barrier, promotes terminal T cell exhaustion, and induces a senescent iCAF…