Senescent T cells within the tumor microenvironment are a potent driver for tumor growth, stemness, and chemotherapy resistance
Cell Reports Medicine · By Yuanqin Zhang, Xia Liu, Yixuan Xie, Lei Zhao, Myung Sik Jeon, Lisha Ai, Jingqin Luo, David A. Ford, Hazar Abusalamah, R. Alex Harbison, Cody Huffman, Jialin Guo, Iris He, Allison Mulvehill, Craig A. Buchman, Sidharth V. Puram, Benjamin A. Garcia, Mark A. Varvares, Marco Colonna & Guangyong Peng ·
Zhang et al. identify that senescent T (Tsen) cells accumulate within tumors and drive tumor growth, metastasis, stemness, and chemotherapy resistance. Mechanistically, lipid-enriched Tsen SASPs reprogram tumor lipid metabolism and activate STAT1/STAT3 signaling. Targeting Tsen…