Research
Rewiring dendritic cell function with CLEC9A and DEC205 CARs
Nature · By Congyi Niu ·
The Brief
- Published online in Nature Immunology on 13 November 2026 (doi:10.1038/s41590-026-02711-3).
- The authors engineer chimeric antigen receptor dendritic cells (CAR-DCs) with CLEC9A and DEC205 CARs to alter specific dendritic cell functions.
- The available excerpt is truncated, so the specific intracellular design and experimental results are not included here.
Why it matters
It shows that T-cell-style chimeric antigen receptor engineering can be applied to dendritic cells to tune their functions, which is relevant to cell-based immunotherapy research.
Who’s affected
- immunologists
- cell therapy and immunotherapy researchers
- #dendritic cells
- #chimeric antigen receptor
- #cell engineering
- #immunotherapy
- #immunology
Nature Immunology, Published online: 13 November 2026; doi:10.1038/s41590-026-02711-3 Chimeric antigen receptor dendritic cells (CAR-DCs) are sometimes engineered in the manner of T cells to enhance specific DC functions. Here, the authors engineer CAR-DCs with the intracellular…
Timeline
Published online in Nature Immunology
nature.com
Rewiring dendritic cell function with CLEC9A and DEC205 CARs