Research
Researchers detect signs of neuronal damage in the earliest stage of Huntington's disease
The Brief
- A study reports signs of neuronal injury in some people carrying the Huntington's disease mutation.
- The neuronal damage was detected before motor or cognitive impairment appears.
- The damage was also seen before brain volume loss becomes evident on imaging.
Why it matters
The findings suggest neuronal injury can be measured in the earliest, presymptomatic stage of Huntington's disease, which could matter for tracking disease onset and evaluating early interventions.
Who’s affected
- researchers and clinicians working on Huntington's disease
- people carrying the Huntington's disease genetic mutation and their families
- #huntingtons disease
- #neurodegeneration
- #presymptomatic
- #neuronal injury
- #genetics
Before motor or cognitive impairments appear and before brain volume loss becomes evident, some individuals carrying the genetic mutation that causes Huntington's disease already show signs of neuronal injury. This is demonstrated by a study conducted by the Institut de Recerca…