Research
Regression to the mean in before-after studies of digestive enzyme replacement in very preterm infants
Nature ·
The Brief
- A nature.com article titled "Regression to the mean in before-after studies of digestive enzyme replacement in very preterm infants" appeared in a subject feed dated 2026-11-11.
- The source provided contains no summary, so the study's methods, sample and findings are not available here.
- The headline indicates the article examines whether regression to the mean can distort before-after studies of digestive enzyme replacement in very preterm infants.
Why it matters
Before-after studies without a comparison group can attribute natural fluctuations or regression to the mean to a treatment, so readers assessing enzyme replacement evidence in very preterm infants should check how such effects were handled.
Who’s affected
- neonatologists and clinicians treating very preterm infants
- researchers designing or reviewing before-after clinical studies
- #neonatology
- #preterm infants
- #enzyme replacement
- #regression to the mean
- #study design