Propionate, a short-chain fatty acid, is associated with disease activity in pediatric-onset multiple sclerosis
Cell Reports Medicine · By Vinicius A. Schoeps, Pavan Bhargava, Gina Chang, Danielle J. Caruso, Dohee Kim, Akash Virupakshaiah, Janet Chong, Gregory Aaen, Jennifer S. Graves, Leslie A. Benson, Mark P. Gorman, Mary Rensel, Aaron W. Abrams, Soe S. Mar, Timothy Lotze, Tanuja Chitnis, Amy T. Waldman, Lauren B. Krupp, Moses Rodriguez, Jan-Mendelt Tillema, John W. Rose, Teri Schreiner, T. Charles Casper, Helen Tremlett, John W. Newman, Kamil Borkowski, Emmanuelle Waubant & the US Network of Pediatric MS Centers ·
In young individuals shortly after multiple sclerosis onset, Schoeps et al. show that higher plasma and stool propionate levels are consistently associated with lower clinical and imaging disease activity. These findings suggest that a gut microbiome-derived short-chain fatty…