Research
Mitochondria-derived extracellular vesicles mediate Alzheimer’s disease pathology through transmitting microglial Ggt1
The Brief
- A study in Nature Aging identifies a pathological role for mitochondria-derived extracellular vesicles (mitovesicles) in Alzheimer's disease.
- The authors used patient brain samples and mouse models.
- The study identifies Ggt1 within mitovesicles and reports that mitovesicles transmit microglial Ggt1 in mediating Alzheimer's pathology.
Why it matters
The work points to a specific intercellular route, mitovesicles carrying Ggt1 from microglia, that may contribute to Alzheimer's pathology, which could inform future research into therapeutic targets.
Who’s affected
- neuroscientists and researchers studying Alzheimer's disease
- #alzheimer's
- #mitochondria
- #microglia
- #extracellular vesicles
- #ggt1
- #neurodegeneration
Nature Aging, Published online: 10 November 2026; doi:10.1038/s43587-026-01263-3 Li, Xia, Sun, Jia et al. identify a pathological role for mitovesicles in Alzheimer’s disease using patient brain samples and mouse models. Within mitovesicles, the authors identify Ggt1 as an…
Timeline
Study published online in Nature Aging (doi:10.1038/s43587-026-01263-3)
nature.com
Mitochondria-derived extracellular vesicles mediate Alzheimer’s disease pathology through transmitting microglial Ggt1