Research
Depth-enhanced molecular imaging with two-photon oblique plane microscopy
Nature · By Kevin Keomanee-Dizon ·
The Brief
- Two-photon oblique plane microscopy combines high-numerical-aperture single-objective detection with two-photon light-sheet illumination.
- The method is reported to resolve subcellular and single-molecule dynamics.
- The paper was published online in Nature Communications on 13 November 2026 (doi:10.1038/s41467-026-78668-6).
Why it matters
The paper describes an imaging approach aimed at deeper molecular-scale imaging, which could matter to researchers who study dynamics inside cells and tissues.
Who’s affected
- cell biologists and neuroscientists who use fluorescence microscopy
- microscopy developers and imaging facility staff
- #microscopy
- #two-photon imaging
- #light-sheet microscopy
- #single-molecule imaging
- #oblique plane microscopy
Nature Communications, Published online: 13 November 2026; doi:10.1038/s41467-026-78668-6 Two-photon oblique plane microscopy combines high-numerical-aperture single-objective detection with two-photon light-sheet illumination, resolving subcellular and single-molecule dynamics…
Timeline
Published online in Nature Communications
nature.com
Depth-enhanced molecular imaging with two-photon oblique plane microscopy