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Circulating HSPCs enhance their self-renewal by augmenting the endocytosis and lysosomal acidity via MIF-(CXCR4_CD74)-ATP6V1A axis

Nature ·

The Brief

  • A study reports that circulating hematopoietic stem and progenitor cells (HSPCs) enhance their self-renewal.
  • The reported mechanism involves increased endocytosis and lysosomal acidity.
  • The headline names a MIF-(CXCR4_CD74)-ATP6V1A axis as the pathway involved.

Why it matters

It offers a proposed molecular mechanism by which circulating blood stem cells maintain self-renewal, which is relevant to stem cell and hematopoiesis research.

Who’s affected

  • stem cell and hematology researchers
Read the full story at nature.com ↗

Timeline

  1. Study listed in nature.com biological sciences subject feed

  2. Biological sciences : nature.com subject feeds

    Circulating HSPCs enhance their self-renewal by augmenting the endocytosis and lysosomal acidity via MIF-(CXCR4_CD74)-ATP6V1A axis

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    Circulating HSPCs enhance their self-renewal by augmenting the endocytosis and lysosomal acidity via MIF-(CXCR4_CD74)-ATP6V1A axis – The Morning Science