Research
An LHX2-DACH1 regulatory innovation drives basal progenitor expansion in the primate neocortex
Science · By Pei-Shan Hou, Ching-Yu Chuang, Feng-Lan Chiu, Chan-Hsien Yeh, Shih-Shun Hung, Quan Wu, Taeko Suetsugu, Fumio Matsuzaki, Shen-Ju Chou & Hung-Chih Kuo ·
The Brief
- A study in Science Advances reports an LHX2-DACH1 regulatory innovation linked to basal progenitor expansion in the primate neocortex.
- The paper appeared in Science Advances Volume 12, Issue 46, in November 2026.
- The available source is the journal listing; its full methods and results were not provided.
Why it matters
The work points to a specific gene-regulatory change that may help explain how the primate neocortex gained its expanded progenitor population, a key question in brain evolution and development.
Who’s affected
- developmental neuroscientists
- evolutionary biologists
- #neocortex
- #neurodevelopment
- #basal progenitors
- #gene regulation
- #primate evolution
Science Advances, Volume 12, Issue 46 , November 2026.
Timeline
Published in Science Advances (Volume 12, Issue 46)
science.org
An LHX2-DACH1 regulatory innovation drives basal progenitor expansion in the primate neocortex