Research
A single-cell lung cancer atlas reveals cellular and molecular drivers of metastasis and clinical outcome
Nature · By Philipp Jurmeister ·
The Brief
- A multicenter single-nucleus RNA sequencing atlas of lung cancer was published in Nature Cancer on 12 November 2026.
- The atlas combines single-nucleus RNA sequencing with spatial transcriptomics and clinical outcome data.
- The authors report cancer–host cell interactions linked to metastasis and clinical outcome.
Why it matters
The study links cell-level tumour and host-cell patterns to metastasis and patient outcomes, providing a reference resource for lung cancer research.
Who’s affected
- lung cancer researchers
- oncologists and clinical researchers interested in metastasis
- #lung cancer
- #single-cell sequencing
- #metastasis
- #spatial transcriptomics
- #tumour microenvironment
Nature Cancer, Published online: 12 November 2026; doi:10.1038/s43018-026-01260-w Jurmeister et al. present a multicenter single-nucleus RNA sequencing atlas of lung cancer combined with spatial transcriptomics and clinical outcomes, delineating cancer–host cell interactions and…
Timeline
Study published online in Nature Cancer (doi:10.1038/s43018-026-01260-w)
nature.com
A single-cell lung cancer atlas reveals cellular and molecular drivers of metastasis and clinical outcome