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A 100% Fatal Disease Just Found a Treatment
The Brief
- In April, the first patients were dosed with a new drug for prion disease, which the description says no patient in recorded medical history has survived.
- The description suggests that if the drug works, Alzheimer's and Parkinson's might be next in line.
- The video's chapters cover how prions reproduce, where they come from, and approaches such as destroying the protein or turning down its gene.
- Later chapters cover building a stronger siRNA, pointing it at prions, moving from mouse studies to humans, and the first human trial.
Why watch · It follows a first-in-human trial of a treatment approach for a disease that is fatal in every recorded case, and asks whether the approach could extend to more common neurodegenerative diseases.
- Prion disease
- siRNA
- Alzheimer's
- Parkinson's
Summarised by Claude from the video’s title and description – no transcript was available, so check the video for the details.
Chapters
- 0:00The Disease You Can't Survive
- 1:26How Does a Protein Reproduce?
- 4:49Where Do Prions Come From?
- 8:03Ad Read
- 9:11Can We Destroy the Protein Itself?
- 10:10What If We Turn the Gene Down?
- 13:01Building a Stronger siRNA
- 15:05Pointing It at Prions
- 17:45From Mouse to Human
- 19:18The First Human Trial
- 20:21Could This Unlock a Whole Class of Diseases?
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Join Revolut and get $20 here! https://get.revolut.com/z4lF/benmiles Offer expires 6 months from 10/06/2026. Exclusions apply. $20 bonus paid by Revolut subject to the terms and conditions found: Revolut x Partner Sign Up Bonus | Revolut United States In April, the first patients were dosed with a new drug for prion disease, a condition that no patient in recorded medical history has ever survived. If it works, Alzheimer's and Parkinson's might be next in line. 🧑🔬👩🔬 Are you a scientists and want to change the world? (Join our waitlist) https://forms.gle/b6zW19Z5NzTjS8gy8 🚀Have a breakthrough technology? https://cypress-flame-692.notion.site/3edb4680b48280eaa97af90f8117638d?pvs=105 🎥 Want to be featured on the show? https://linktr.ee/drbenmiles 🔗 My other links https://linktr.ee/drbenmiles 🙌 Support our work: http://patreon.com/DrBenMiles Chapters 0:00 The Disease You Can't Survive 1:26 How Does a Protein Reproduce? 4:49 Where Do Prions Come From? 8:03 Ad Read 9:11 Can We Destroy the Protein Itself? 10:10 What If We Turn the Gene Down? 13:01 Building a Stronger siRNA 15:05 Pointing It at Prions 17:45 From Mouse to Human 19:18 The First Human Trial 20:21 Could This Unlock a Whole Class of Diseases? #sponsored My Patreon:🚀 http://patreon.com/DrBenMiles My Instagram: https://www.instagram.com/drbenmiles My TikTok: https://www.tiktok.com/@drbenmiles My Newsletter: https://drbenmiles.substack.com/ My Merch: https://www.rockstarscientist.org/ 🔗 Linktree: https://linktr.ee/drbenmiles MY GEAR 📷 Sony A7III https://amzn.to/3OWrmGd 🔎 Sigma 402965 16 mm F1.4 https://amzn.to/49BNJdq 🎤 Shure SM7B https://amzn.to/4sF3ngx 🎤 Zoom H4n Pro https://amzn.to/3OXsklB 🎤 Sennheiser AVX https://amzn.to/4geWnBi