Research
WASH orchestrates phagosomal maturation and bacterial killing in neutrophils through syntaxin 19-mediated lysosomal fusion
Nature · By Elsa Meneses-Salas ·
The Brief
- WASH drives actin-dependent lysosomal dynamics in neutrophils, according to the study.
- The authors report that WASH regulates late phagosomal maturation through STX19-mediated lysosomal fusion.
- The work links this pathway to bacterial killing by neutrophils.
Why it matters
It clarifies how actin regulates the maturation of phagosomes and the killing of microbes in neutrophils, a basic mechanism of innate immunity that cell biologists and immunologists can build on.
Who’s affected
- Researchers studying neutrophil phagocytosis and innate immunity
- #neutrophils
- #phagosome
- #lysosome
- #actin
- #innate-immunity
- #membrane-trafficking
Nature Communications, Published online: 07 November 2026; doi:10.1038/s41467-026-79065-9 How actin regulates late phagosomal maturation and microbial killing in neutrophils remains unclear. The authors here show that WASH drives actin-dependent lysosomal dynamics and STX19…
Timeline
Published online in Nature Communications
nature.com
WASH orchestrates phagosomal maturation and bacterial killing in neutrophils through syntaxin 19-mediated lysosomal fusion