Research
Tumor-colonizing Bifidobacterium dentium promotes tumor progression and chemotherapy resistance via MMP3 and GABA-FOXA2-P-gp axis
Cell Reports Medicine · By Xiaoyun Pan, Shuyi Luo, Shuheng Dou, Yiqiu Li, Chanci Qiu, Qiao Pan, Xiaoshi Zhang, Ge Zhang & Songhe Guo ·
The Brief
- Pan et al. report that Bifidobacterium dentium colonizing tumours promotes tumour progression and resistance to chemotherapy.
- The study links B. dentium to induction of MMP3.
- The authors describe a GABA-FOXA2-P-gp axis through which the bacterium promotes P-gp upregulation.
Why it matters
It suggests that microbes inside tumours can influence how cancers respond to chemotherapy, pointing to host-microbe interactions as a possible factor in treatment resistance.
Who’s affected
- cancer researchers
- microbiome researchers
- oncology clinicians
- #microbiome
- #chemotherapy resistance
- #tumour microenvironment
- #bifidobacterium
- #cancer biology
Pan et al. report that tumor-colonizing B. dentium promotes tumor progression and chemotherapy resistance. Their findings link B. dentium to MMP3 induction and GABA-mediated FOXA2-dependent P-gp upregulation, supporting a role for intratumoral host-microbe interactions in tumor…
Timeline
Study published in Cell Reports Medicine
cell.com
Tumor-colonizing Bifidobacterium dentium promotes tumor progression and chemotherapy resistance via MMP3 and GABA-FOXA2-P-gp axis