Research
TRIM47 drives cardiac ischemia/reperfusion injury by impairing mitochondrial function and fatty acid metabolism in male mice
The Brief
- The study reports that TRIM47 drives cardiac ischaemia/reperfusion injury in male mice.
- According to the source, TRIM47 impairs mitochondrial function and fatty acid metabolism.
- The authors report that TRIM47 facilitates ubiquitination-dependent nuclear translocation of FOXO1.
Why it matters
Cardiac ischaemia/reperfusion injury is described as a prevalent and hard-to-treat clinical complication, and the study points to the TRIM47–FOXO1 pathway as a possible target, though the findings so far are reported only in male mice.
Who’s affected
- cardiologists and cardiac researchers
- researchers studying ischaemia/reperfusion injury, mitochondrial function and cardiac metabolism
- #cardiology
- #ischaemia-reperfusion
- #mitochondria
- #fatty-acid-metabolism
- #foxo1
- #mouse-model
Nature Communications, Published online: 14 November 2026; doi:10.1038/s41467-026-79182-5 Cardiac I/R injury is a prevalent and intractable clinical complication. Here, the authors show that TRIM47 facilitates ubiquitination-dependent nuclear translocation of FOXO1 and the…
Timeline
Published online in Nature Communications
nature.com
TRIM47 drives cardiac ischemia/reperfusion injury by impairing mitochondrial function and fatty acid metabolism in male mice