Research
TMEM192 is a calcineurin-regulated membrane receptor for ubiquitin-independent lysophagy
Nature · By Xinchang Liu ·
The Brief
- Liu et al. report that TMEM192 acts as a ubiquitin-independent lysophagy receptor.
- Lysosomal calcium activates calcineurin, which dephosphorylates TMEM192 to expose an LC3-binding site.
- The study was published online in Nature Cell Biology on 12 November 2026.
Why it matters
It describes a route for clearing damaged lysosomes that does not require ubiquitin tagging, which matters for researchers studying lysosomal quality control and autophagy.
Who’s affected
- cell biologists studying autophagy and lysosomes
- #lysophagy
- #autophagy
- #lysosome
- #calcineurin
- #membrane receptor
Nature Cell Biology, Published online: 12 November 2026; doi:10.1038/s41556-026-02135-z Liu et al. show that TMEM192 is a ubiquitin-independent lysophagy receptor. Lysosomal calcium activates calcineurin, which dephosphorylates TMEM192 to expose an LC3-binding site, initiating…
Timeline
Published online in Nature Cell Biology
nature.com
TMEM192 is a calcineurin-regulated membrane receptor for ubiquitin-independent lysophagy