Research
The optogenetic tool ASAP acutely inhibits autophagy
Nature · By Payel Mondal ·
The Brief
- Mondal et al. present ASAP, an optogenetic tool designed to rapidly inhibit autophagy.
- Proteomic profiling with ASAP identifies the most tightly regulated autophagy substrates, including nuclear pore components.
- The work was published online in Nature Cell Biology on 12 November 2026.
Why it matters
ASAP gives researchers light-controlled, acute inhibition of autophagy, allowing them to separate direct autophagy targets from downstream effects of longer-term inhibition.
Who’s affected
- cell biologists studying autophagy
- researchers using optogenetic tools to control cellular processes
- #autophagy
- #optogenetics
- #proteomics
- #cell biology
Nature Cell Biology, Published online: 12 November 2026; doi:10.1038/s41556-026-02124-2 Mondal et al. present an optogenetic tool to rapidly inhibit autophagy, named ASAP. Proteomic profiling with ASAP shows the most tightly regulated autophagy substrates, including nuclear pore…
Timeline
Published online in Nature Cell Biology
nature.com
The optogenetic tool ASAP acutely inhibits autophagy