Research
The C-terminal tail of the RBR E3 ligase RNF14 defines branched K6/K48 polyubiquitin specificity in ribosomal quality control
Molecular Cell · By Sarah J. Trevelyan, Jenny Riedel, Yeh Huei Tong, Hao Dong, Jenny Jiou, Erin N.S. McGowan, Xiangyi S. Wang, Simon A. Cobbold, Rebecca Feltham & Bernhard C. Lechtenberg ·
The Brief
- Trevelyan et al. report that the E3 ubiquitin ligase RNF14 forms branched K6/K48 polyubiquitin.
- The study identifies the C-terminal tail of RNF14 as a critical component for its chain-type and branching activity.
- The work is framed as relevant to ribosomal quality control.
Why it matters
It clarifies how a specific E3 ligase builds a particular branched ubiquitin chain, a step that could matter for understanding how damaged ribosomal translation is handled in cells.
Who’s affected
- researchers studying ubiquitin signalling and protein quality control
- structural and molecular biologists working on E3 ligases
- #ubiquitin
- #e3 ligase
- #ribosomal quality control
- #rnf14
- #polyubiquitin
Trevelyan et al. report that the E3 ubiquitin ligase RNF14 forms branched K6/K48 polyubiquitin and identify RNF14’s C-terminal tail as a critical component for its chain-type and branching activity. This work opens research avenues for branched K6/K48 ubiquitin in ribosomal…