Research
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins
Nature · By Xianghua Li ·
The Brief
- TF-MAPS is a scalable platform for charting functional maps of sequence-specific DNA-binding proteins.
- The study, by Li and Lehner, was published online in Nature Structural & Molecular Biology on 11 November 2026.
- The authors use TF-MAPS to map allostery in three transcription factors.
Why it matters
It offers a faster, higher-resolution way to map how DNA-binding proteins function and how allosteric effects propagate through them, which can inform studies of gene regulation.
Who’s affected
- structural and molecular biologists studying transcription factors
- researchers working on gene regulation and allostery
- #transcription factors
- #allostery
- #dna-binding proteins
- #protein function
- #structural biology
Nature Structural & Molecular Biology, Published online: 11 November 2026; doi:10.1038/s41594-026-01908-2 Li and Lehner present TF-MAPS, a scalable platform to chart functional maps of sequence-specific DNA-binding proteins. The authors map allostery in three transcription…
Timeline
Published online in Nature Structural & Molecular Biology
nature.com
TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins