Research
Tachykinin-like NLP-58 signaling through TKR-1 modulates thermotaxis behavior in Caenorhabditis elegans
PLOS ·
The Brief
- A PLOS Genetics paper reports that tachykinin-like neuropeptide NLP-58 signalling through its receptor TKR-1 modulates thermotaxis behaviour in the nematode Caenorhabditis elegans.
- The study is framed by the central role of neurokinin B signalling in mammalian thermoregulatory dysfunction.
- The paper's authors include Moon Sun Jang, Hironori J. Matsuyama and Ikue Mori.
Why it matters
The work identifies a specific neuropeptide pathway that shapes how C. elegans moves in response to temperature, offering a simple genetic model for studying neuropeptide control of thermosensory behaviour.
Who’s affected
- neuroscientists studying thermosensation and neuropeptide signalling
- C. elegans researchers
- #c. elegans
- #thermotaxis
- #neuropeptides
- #tachykinin
- #thermosensation
by Moon Sun Jang, Hironori J. Matsuyama, Ryoga Suzuki, King Chuen Law, Yukimasa Shibata, Xiaolin Zhang, Koutarou D. Kimura, Yukihiko Kubota, Masahiro Ito, Kiyoji Nishiwaki, Ikue Mori Neurokinin B (NKB) signaling plays a central role in mammalian thermoregulatory dysfunction…