Research
STAT3 controls IL-6–induced epigenomic remodeling and restrains a latent STAT1-associated interferon program in human macrophages
Science · By Yebin Park, Geunho Kwon, Junho Noh, Jaehyun Lee, Keunsoo Kang, Kyung-Hyun Park-Min & Kyuho Kang ·
The Brief
- A Science Advances study reports that STAT3 controls IL-6-induced epigenomic remodelling in human macrophages.
- The authors report that STAT3 also restrains a latent STAT1-associated interferon program in these cells.
Why it matters
It clarifies how IL-6 signalling reshapes gene regulation in human macrophages, which is relevant to understanding inflammatory and interferon-related immune responses.
Who’s affected
- immunologists
- researchers studying macrophage gene regulation and epigenomics
- #stat3
- #il-6
- #macrophages
- #epigenomics
- #interferon
Science Advances, Volume 12, Issue 46 , November 2026.
Timeline
Study published in Science Advances (Volume 12, Issue 46)
science.org
STAT3 controls IL-6–induced epigenomic remodeling and restrains a latent STAT1-associated interferon program in human macrophages