Research
Spatiotemporal dynamics of adoptively transferred stem-like CD8+ T cells in the tumor microenvironment following vaccination
Cell Reports Medicine · By Dalton Hermans, Sloane C. Fussell, Ramiro A. Ramirez-Valdez, Sam Shepard, Remi Poulard, Sonia Zumalave, Benjamin Sievers, Christopher M. Garliss, Vincent L. Coble, Geoffrey M. Lynn, Andrew S. Ishizuka, Isidro Cortes-Ciriano & Robert A. Seder ·
The Brief
- Adoptively transferred stem-like CD8+ T cells combined with intravenous vaccination were studied for their spatiotemporal dynamics in the tumor microenvironment.
- The study reports that this combination reshapes the tumor environment to promote immune infiltration and tumor control.
- The findings are published in Cell Reports Medicine by Hermans et al.
Why it matters
The work describes how high-quality T cells and systemic vaccination may work together in adoptive cell therapy, which informs the design of future immunotherapy combinations.
Who’s affected
- cancer immunologists and researchers in adoptive cell therapy
- clinicians and developers of T cell-based cancer treatments
- #cd8 t cells
- #adoptive cell therapy
- #cancer vaccines
- #tumor microenvironment
- #immunotherapy
Hermans et al. show that adoptive cell therapy combining stem-like CD8+ T cells with intravenous vaccination reshapes the tumor environment to promote immune infiltration and tumor control. The findings reveal how high-quality T cells and systemic vaccination can work together to…
Timeline
Study published in Cell Reports Medicine
cell.com
Spatiotemporal dynamics of adoptively transferred stem-like CD8+ T cells in the tumor microenvironment following vaccination