Research
Site-specific N-glycoproteomic analysis of extracellular vesicles from seminal plasma reveals the molecular typing of azoospermia
Nature · By Mingyang Li ·
The Brief
- The study presents EVGlyco, a low-input platform for site-specific N-glycoproteomic analysis of biofluid extracellular vesicles.
- It identifies site-specific N-glycan signatures in seminal plasma extracellular vesicles.
- The authors report these signatures as a molecular typing of azoospermia.
Why it matters
It proposes a molecular way to subtype azoospermia from glycosylation patterns in seminal plasma extracellular vesicles, which could inform future diagnostic research.
Who’s affected
- clinicians and researchers in male reproductive health
- glycoproteomics and extracellular vesicle researchers
- #azoospermia
- #extracellular vesicles
- #glycoproteomics
- #seminal plasma
- #male infertility
Nature Communications, Published online: 15 November 2026; doi:10.1038/s41467-026-79570-x This study presents EVGlyco, a low-input platform for site-specific N-glycoproteomic analysis of biofluid EVs. It identifies site-specific N-glycan signatures in seminal plasma EVs that…
Timeline
Published online in Nature Communications
nature.com
Site-specific N-glycoproteomic analysis of extracellular vesicles from seminal plasma reveals the molecular typing of azoospermia