Self-amplifying RNA vaccines encoding chimeric and mosaic hemagglutinins confer immunity against phylogenetically diverse influenza A viruses
Cell Reports · By Anass Abbad, Temima Yellin, Juan Manuel Carreño, Justine S. McPartlan, Poulami Talukder, Eduard Puente-Massaguer, Irene González-Domínguez, Michael Scherm, Dominika Bielak, Brian Lerman, Christian W. Mandl, Jasdave S. Chahal & Florian Krammer ·
Seasonal influenza vaccines require annual reformulation and offer limited protection. Abbad et al. show that self-amplifying mRNA vaccines encoding chimeric and mosaic hemagglutinins elicit broadly protective antibodies against diverse influenza A virus strains, acting largely…