Research
Reciprocal constraints couple architectural protein abundance and pericentromeric satellite expansion
Current Biology · By Damian Dudka, Keagan Beeravolu, Jun Ma & Michael A. Lampson ·
The Brief
- In mouse oocytes, abundance of the architectural protein HMGA2 correlates with the copy number of pericentromeric major satellite DNA.
- Low HMGA2 disrupts packaging of large satellite arrays.
- High HMGA2 causes aneuploidy when satellite arrays are small.
Why it matters
The study shows that the level of a chromatin-packaging protein and the size of repeat arrays constrain each other, which bears on how chromosome segregation errors arise in oocytes.
Who’s affected
- chromatin and meiosis researchers
- reproductive biologists
- #chromatin
- #satellite dna
- #oocytes
- #aneuploidy
- #hmga2
Dudka et al. show that abundance in oocytes of architectural protein HMGA2, which packages mouse major satellite DNA, correlates with satellite copy number. Low HMGA2 disrupts packaging of large satellite arrays, whereas high HMGA2 causes aneuploidy when arrays are small…
Timeline
Study published in Current Biology
cell.com
Reciprocal constraints couple architectural protein abundance and pericentromeric satellite expansion