Research
PKA signaling controls ILC3 homeostasis and IL-23-mediated inflammation in the gut
The Brief
- Prostaglandin engages protein kinase A (PKA) in ILC3 cells, according to the Nature Immunology study by Sonnenberg and colleagues.
- Sustained PKA activation promotes the depletion of ILC3s.
- IL-23 can drive aberrant PKA signaling, which is linked to gut inflammation.
Why it matters
The study identifies a signalling pathway that controls ILC3 cell numbers and IL-23-driven inflammation in the gut, which may inform future work on intestinal inflammatory disease.
Who’s affected
- immunologists
- researchers studying gut inflammation and innate lymphoid cells
- #ilc3
- #pka signalling
- #gut inflammation
- #il-23
- #prostaglandin
- #immunology
Nature Immunology, Published online: 11 November 2026; doi:10.1038/s41590-026-02703-3 Sonnnenberg and colleagues show that prostaglandin engages protein kinase A (PKA) and sustained PKA activation promotes the depletion of ILC3s. IL-23 can drive aberrant PKA signaling resulting…
Timeline
Published online in Nature Immunology
nature.com
PKA signaling controls ILC3 homeostasis and IL-23-mediated inflammation in the gut