PARP1 hyperactivation uncouples transcription from protein expression through nuclear RNA retention
Molecular Cell · By Pedro Ortega, Elodie Bournique, Ambrocio Sanchez, Gisselle Santiago, Dong-Min Lee, Katrina M. Yan, Lavanya Manjunath, Marina Norfolk, Vyanka Mezcord, Junyi Li, Jessie A.C. Altieri, Lucas Wadley, Yongsheng Shi, Klemen J. Hertel, Justin W. Leung & Rémi Buisson ·
Ortega et al. show that PARP1 hyperactivation suppresses translation by promoting nuclear RNA retention. APE1-dependent cleavage of abasic sites triggers PARP1 hyperactivation, increasing nuclear PAR, which competes with RNA for binding to RNA-binding proteins. This disrupts RNA…