Research
Nudix protein D250R promotes African swine fever virus infection by disrupting host ubiquitination machinery
Nature · By Jiwen Zhang ·
The Brief
- A Nature Communications study reports that the African swine fever virus protein D250R promotes infection.
- The study describes an immune-evasion mechanism in which the virus targets ubiquitin activation.
- According to the abstract, loss of D250R attenuates the virus, which identifies D250R as a key virulence factor.
Why it matters
The findings identify a specific viral protein and host ubiquitination pathway involved in African swine fever virus infection, which may inform future antiviral or vaccine research.
Who’s affected
- researchers studying African swine fever virus and host immune evasion
- virologists working on ubiquitin signalling
- #african swine fever
- #virology
- #ubiquitination
- #immune evasion
- #nudix protein
Nature Communications, Published online: 11 November 2026; doi:10.1038/s41467-026-79340-9 This study uncovers a novel African swine fever virus (ASFV) immune-evasion mechanism targeting ubiquitin activation and identifies D250R as a key virulence factor. Loss of D250R attenuates…
Timeline
Study published online in Nature Communications
nature.com
Nudix protein D250R promotes African swine fever virus infection by disrupting host ubiquitination machinery