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Non-overlapping rather than “opposing” effects of microglial and macrophagic C3ar1 signaling

Nature · By Zhiqian Yu ·

The Brief

  • The study was published online in Molecular Psychiatry on 11 November 2026 (doi:10.1038/s41380-026-03961-1).
  • The paper reports that microglial and macrophagic C3ar1 signalling have non-overlapping rather than opposing effects.
  • The sources provided contain only the article's title and publication details, so no further findings can be reported.

Why it matters

It suggests that C3ar1 signalling in microglia and in macrophages should be studied as separate processes, since the two cell types may not act in opposition.

Who’s affected

  • neuroscientists and immunologists studying microglia and complement signalling

Molecular Psychiatry, Published online: 11 November 2026; doi:10.1038/s41380-026-03961-1 Non-overlapping rather than “opposing” effects of microglial and macrophagic C3ar1 signaling

Timeline

  1. Published online in Molecular Psychiatry

  2. nature.com

    Non-overlapping rather than “opposing” effects of microglial and macrophagic C3ar1 signaling

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