Research
Microbiome-antibiotic-immune interactions influence mortality in preterm infant gut microbiota-humanized gnotobiotic mice
Cell Reports Medicine · By Drew J. Schwartz, Galen G. Wong, Kate E. Wardenburg, Isabel R. Erickson, Jessica Tung, Jie Ning, Lingxia Zhao, Nitan Shalon, Alaric W. D’Souza, Aura Ferreiro, Rachel B. Silverstein, Terence S. Crofts, Carla Hall-Moore, Meghan A. Wallace, John I. Robinson, Jeffrey P. Henderson, Carey-Ann D. Burnham, Barbara B. Warner, Phillip I. Tarr & Gautam Dantas ·
The Brief
- Schwartz et al. studied gnotobiotic mouse pups colonized with stool from preterm infants.
- The study reports associations between antibiotic administration, systemic immune responses, microbiome composition, and death in these mice.
- The findings are associative and come from a mouse model.
Why it matters
Antibiotic use is common in preterm infants, and this work links antibiotics, immune responses and gut microbiome composition with mortality in a humanized mouse model, which could guide future research on neonatal care.
Who’s affected
- neonatal researchers and clinicians
- microbiome researchers
- #preterm infants
- #gut microbiome
- #antibiotics
- #immunity
- #mouse models
Preterm infants are commonly treated with antibiotics. Schwartz et al. discover associations between antibiotic administration, systemic immune responses, microbiome composition, and death in gnotobiotic mouse pups humanized with stool from preterm infants. These findings can…
Timeline
Study published in Cell Reports Medicine
cell.com
Microbiome-antibiotic-immune interactions influence mortality in preterm infant gut microbiota-humanized gnotobiotic mice