Research
Mechanosensitive YAP–RUNX1 signaling drives T H 1 cell dysfunction and tumor immunosuppression
The Brief
- Solid tumor stiffness can limit the ability of immune cells to enter and kill tumor cells.
- The authors report that this stiffness activates YAP signaling in type 1 helper (TH1) T cells.
- The study links YAP–RUNX1 signaling to TH1 cell dysfunction and tumor immunosuppression.
Why it matters
It identifies a mechanical property of tumors, their stiffness, as a route to immune suppression in TH1 cells, which may matter for designing cancer immunotherapies.
Who’s affected
- immunologists and cancer researchers
- #immunology
- #cancer
- #t cells
- #mechanobiology
- #tumor microenvironment
Nature Immunology, Published online: 09 November 2026; doi:10.1038/s41590-026-02708-y Solid tumor stiffness can limit the ability of immune cells to enter and kill tumor cells. Here the authors show that this stiffness activates YAP signaling in type 1 helper T cells, making them…
Timeline
Published online in Nature Immunology
nature.com
Mechanosensitive YAP–RUNX1 signaling drives T H 1 cell dysfunction and tumor immunosuppression