Research
Mapping mammalian placental formation and implantation transitions with single-cell transcriptomics and live imaging
Nature · By Dong-Yuan Chen ·
The Brief
- Chen, Hu et al. performed single-cell transcriptomics on peri-implantation mouse embryos.
- The authors filmed embryo implantation using live imaging.
- They report that the mural trophectoderm population is an essential component of placental formation and implantation.
Why it matters
The study links single-cell gene expression maps with live imaging of early mouse embryos, offering a detailed view of how the placenta forms and implants that developmental biologists can use as a reference.
Who’s affected
- developmental biologists
- reproductive biologists
- #placenta
- #embryo implantation
- #single-cell transcriptomics
- #trophectoderm
- #mouse embryo
- #live imaging
Nature Cell Biology, Published online: 12 November 2026; doi:10.1038/s41556-026-02134-0 Chen, Hu et al. perform single-cell transcriptomics on peri-implantation mouse embryos and film embryo implantation. They find that mural trophectoderm population is an essential component of…
Timeline
Published online in Nature Cell Biology
nature.com
Mapping mammalian placental formation and implantation transitions with single-cell transcriptomics and live imaging