Research2 sources
Low-order assemblies drive oncogenic RTK fusion signalling without condensation
Nature · By David Gonzalez-Martinez ·
The Brief · written from 2 sources
- Cytoplasmic condensates formed by receptor tyrosine kinase (RTK) fusion oncoproteins had been implicated in regulating oncogenic signalling.
- Gonzalez-Martinez, Mumford et al. show that the condensate-forming fusion oncoprotein EML4–ALK can drive oncogenic Ras–Erk signalling from small multimers in the dilute phase.
- The paper is published in Nature Cell Biology on 13 November 2026 (doi:10.1038/s41556-026-02112-6), with a companion article (doi:10.1038/s41556-026-02114-4).
Why it matters
The findings suggest that condensation is not required for EML4–ALK to drive Ras–Erk signalling, which may change which molecular features researchers target when studying RTK fusion oncoproteins.
Who’s affected
- cancer biologists
- researchers studying RTK fusion oncoproteins
- researchers studying biomolecular condensates
- #oncogenic signalling
- #receptor tyrosine kinase
- #biomolecular condensates
- #eml4-alk
- #ras-erk signalling
Nature Cell Biology, Published online: 13 November 2026; doi:10.1038/s41556-026-02112-6 Gonzalez-Martinez, Mumford et al. show that condensate-forming fusion oncoprotein EML4–ALK can drive oncogenic Ras–Erk signalling from small multimers in the dilute phase, whereas its…
Timeline
Study published online in Nature Cell Biology
nature.com
Diffuse assemblies drive oncogenic signalling
nature.com
Low-order assemblies drive oncogenic RTK fusion signalling without condensation