Research
KAS-CUT&Tag for direct mapping of transcription bubbles
Nature · By Weifang Wu ·
The Brief
- KAS-CUT&Tag is a new method that maps transcription bubbles, the transiently unwound DNA regions during transcription, directly.
- Current methods track DNA unwinding during transcription only indirectly, according to the source.
- The method is reported in Nature Structural & Molecular Biology by Wu et al., published online 13 November 2026.
Why it matters
Direct mapping of transcription bubbles gives researchers a more direct view of an early step in gene transcription than indirect methods provide.
Who’s affected
- molecular biologists studying transcription and chromatin
- genomics researchers using CUT&Tag-style profiling
- #transcription
- #chromatin
- #genomics
- #dna-unwinding
- #cut-and-tag
Nature Structural & Molecular Biology, Published online: 13 November 2026; doi:10.1038/s41594-026-01917-1 During transcription, DNA briefly unwinds, but current methods track this process indirectly. Wu et al. develop KAS-CUT&Tag to map transcription bubbles and associated…
Timeline
Study published online in Nature Structural & Molecular Biology
nature.com
KAS-CUT&Tag for direct mapping of transcription bubbles