Research
Inverse correlation between a putative surrogate marker reflecting aldehyde oxidase activity and urinary hypoxanthine/xanthine ratio in Xdh knockout mice
Nature ·
The Brief
- A Scientific Reports article reports an inverse correlation between a putative surrogate marker of aldehyde oxidase activity and the urinary hypoxanthine/xanthine ratio in Xdh knockout mice.
- The study was listed in nature.com's biological sciences subject feed on 2026-11-10.
- The marker is described as putative, so its validity as a surrogate has not been established by the source material provided.
Why it matters
It suggests a urinary measure might serve as a proxy for aldehyde oxidase activity in a mouse model, which could matter to researchers studying purine metabolism and related enzymes.
Who’s affected
- researchers in purine metabolism and xanthine oxidoreductase biology
- #aldehyde oxidase
- #xanthine dehydrogenase
- #purine metabolism
- #urinary biomarkers
- #knockout mice
Timeline
Study listed in nature.com biological sciences subject feed
Biological sciences : nature.com subject feeds
Inverse correlation between a putative surrogate marker reflecting aldehyde oxidase activity and urinary hypoxanthine/xanthine ratio in Xdh knockout mice