Research
In situ profiling of plasma cell clonality with image-based single-cell transcriptomics
The Brief
- BCR-MERFISH is an image-based method for in situ profiling of plasma cell clonality.
- It combines V gene-specific detection with spatial transcriptomics to track plasma cell clones.
- The paper was published online in Nature Methods on 10 November 2026.
Why it matters
It offers a way to link clonal identity of plasma cells, based on V gene detection, with gene expression in intact tissue at single-cell resolution.
Who’s affected
- immunologists and spatial biology researchers
- #spatial transcriptomics
- #plasma cells
- #b cell receptor
- #clonality
- #single-cell
Nature Methods, Published online: 10 November 2026; doi:10.1038/s41592-026-03296-3 BCR-MERFISH enables tracking of plasma cell clones by combining V gene-specific detection with spatial transcriptomics.
Timeline
Published online in Nature Methods (doi:10.1038/s41592-026-03296-3)
nature.com
In situ profiling of plasma cell clonality with image-based single-cell transcriptomics