In situ CAR engineering and nanoparticle-mediated TREM2 degradation for macrophage reprogramming in malignant ascites
Nature Materials, Published online: 06 November 2026; doi:10.1038/s41563-026-02769-2 Targeted lipid nanoparticles reprogram TREM2+-tumour-associated macrophages in ascitic fluid into chimeric antigen receptor macrophage cells, providing an in situ cell engineering strategy that…