Research
Identification of the SNHG14/hsa-miR-577/CLIC4 ceRNA axis reveals the association of CLIC4 with stromal activation and microenvironment remodeling in colorectal cancer
Nature ·
The Brief
- The study identifies a SNHG14/hsa-miR-577/CLIC4 competing endogenous RNA (ceRNA) axis in colorectal cancer.
- The authors report an association between CLIC4 and stromal activation.
- The authors also link CLIC4 to microenvironment remodeling in colorectal cancer.
Why it matters
It proposes a molecular link between a non-coding RNA network and tumour stroma in colorectal cancer, which may guide further mechanistic and biomarker research.
Who’s affected
- colorectal cancer researchers
- cancer biologists studying the tumour microenvironment
- #colorectal-cancer
- #cerna
- #lncrna
- #tumor-microenvironment
- #stromal-activation
- #clic4