Identification and regulation of an ACC1-associated lipogenic metabolon in liver
Molecular Cell · By Xiaotong Zhu, William B. McKean, Tam N.T. Tran, Xiaorong Fu, Shawn C. Burgess, Jay D. Horton & Chai-Wan Kim ·
Zhu et al. identify a nutrient-responsive ACC1-centered metabolon that organizes lipid-synthesis enzymes near lipid droplets and associates with intracellular trafficking proteins. ACC1-associated interactions increase in steatotic, insulin-resistant livers, revealing a potential…