Research
Human neocortical glutamatergic neurons revealed through multimodal profiling
Cell Reports · By Rachel Dalley, Sarah Walling-Bell, Jeremy A. Miller, Femke Waleboer, Julian Thijssen, Audrey McCutcheon, Kamiliam Nasirova, Emily Gelfand, Matt Mallory, Cristina Radaelli, Xiao-Ping Liu, Scott Sawchuk, Lauren Alfiler, Julia Andrade, Jeanelle Ariza, Angela Ayala, Katherine S. Baker, Eliza Barkan, Stuard Barta, Kyla Berry, Darren Bertagnolli, Kris Bickley, Madeline Bixby, Krista Blake, Jasmine Bomben, Krissy Brouner, Agata Budzillo, Jazmin Campos, Trangthanh Cardenas, Daniel Carey, Tamara Casper, Anish Bhaswanth Chakka, Michael Clark, Tom V. Coopmans, Kirsten Crichton, Nick Dee, Nadezhda I. Dotson, Stan L.W. Driessens, Tom Egdorf, Lauren Ellingwood, Chris English, Rachel Enstrom, Rebecca de Frates, Anna A. Galakhova, Amanda Gary, Jessica Gloe, Jeff Goldy, Hong Gu, Kristen Hadley, Samantha D. Hastings, Tim S. Heistek, Dijon Hill, Windy Ho, Alvin Huang, Daan C. Jol, Atlas Jordan, Zoe C. Juneau, Matthew Jungert, Madhav Kannan, Sara Kebede, Ayoub J. Khalil, Lisa Kim, Mean-Hwan Kim, Megan Koch, Ágnes Katalin Kocsis, Matthew Kroll, Aditi Kumar, Gabriela Leon, Jocelin Malone, Rusty Mann, Michelle Maxwell, Medea McGraw, Delissa A. McMillen, Eline J. Mertens, Verjinia D. Metodieva, Gábor Molnár, Miranda R. Moore, Alice Mukora, Lindsay Ng, Aaron Oldre, Alana Oyama, Daniel Park, Zoltan Peterfi, Elliot Phillips, Christina Alice Pom, Lydia Potekhina, Ramkumar Rajanbabu, Shea T. Ransford, Ingrid Redford, Christine Rimorin, Dana Rocha, Augustin Ruiz, David Sandman, Natia Shamugia, Ana Rios Sigler, Josef Sulc, Tjerk P. Swinkels, Ildikó Szöts, Michael Tieu, Éva Toth, Alex Tran, Jessica Trinh, Herman Tung, Marshall VanNess, Sara Vargas, Maria Camila Vergara, Katherine Wadhwani, Grace Williams, Laurens Witter, Anubhav G. Amin, Charles Cobbs, Richard Ellenbogen, Samuel Emerson, Manuel Ferreira, Nathan W. Gouwens, Benjamin Grannan, Ryder P. Gwinn, Jason S. Hauptman, Sander Idema, Andrew L. Ko, Lauren Kruse, Brian Long, David Noske, Jeffrey G. Ojemann, Anoop Patel, Jacob J. Ruzevick, Dan L. Silbergeld, Kimberly A. Smith, Niels Verburg, Jack Waters, Tim Jarsky, Boudewijn Lelieveldt, Gábor Tamás, Huibert D. Mansvelder, Natalia A. Goriounova, Christiaan P.J. de Kock, Nikolai C. Dembrow, Jonathan T. Ting, Hongkui Zeng, Ed S. Lein, Brian E. Kalmbach, Staci A. Sorensen & Brian R. Lee ·
The Brief
- Dalley et al. present a layer-resolved patch-seq resource that integrates transcriptomic, morphological, electrophysiological, and spatial data across human neocortical glutamatergic neuron types.
- The study characterizes understudied human L4 IT, L5/6 NP, and L6 neurons.
Why it matters
It gives neuroscientists a multimodal reference for human cortical excitatory neuron types, which is useful for comparing human neurons with those studied in other species and for interpreting cell-type data.
Who’s affected
- neuroscientists studying human cortex
- researchers working on cell-type classification and patch-seq methods
- #neuroscience
- #neocortex
- #patch-seq
- #single-cell
- #electrophysiology
- #transcriptomics
Dalley et al. present a layer-resolved patch-seq resource integrating transcriptomic, morphological, electrophysiological, and spatial data across human neocortical glutamatergic neuron types. The study characterizes understudied human L4 IT, L5/6 NP, and L6 neurons and reveals…
Timeline
Study published in Cell Reports
cell.com
Human neocortical glutamatergic neurons revealed through multimodal profiling