Research
Human antibody combinations determined by epitope mapping of orthopoxvirus A33/A35 confer therapeutic protection in mice
Science · By Anqi Xia, Qiwei Jiang, Xiaojie Wang, Jie Liu, Jiannan Chen, Haozhe Zhao, Siyuan Sun, Wei Wu, Weiyu Jiang, Song Xue, Yi’ou Sha, Yingying Song, Qianqian Zhang, Yaming Li, Liyuan Hu, Haiyu Wang, Yiming Long, Yidan Gao, Yuru Han, Jieliang Chen, Cong Zeng, Lu Lu, Rong Zhang, Rong Xia, Zhenghong Yuan, Xiao Li, Yixiao Zhang & Qiao Wang ·
The Brief
- Researchers mapped the epitopes of the orthopoxvirus A33 and A35 proteins that human antibodies target.
- Certain human antibody combinations based on this epitope mapping conferred therapeutic protection in mice.
- The study was published in Science Translational Medicine, Volume 18, Issue 875, November 2026.
Why it matters
The results show that specific combinations of human antibodies against defined orthopoxvirus targets can protect animals after infection in a mouse model, which informs how antibody-based treatments for orthopoxvirus infections might be designed.
Who’s affected
- researchers in virology and immunology
- public health and biodefense planners working on orthopoxvirus countermeasures
- #orthopoxvirus
- #antibodies
- #epitope mapping
- #therapeutics
- #mouse models
Science Translational Medicine, Volume 18, Issue 875 , November 2026.
Timeline
Study published on science.org in Science Translational Medicine
science.org
Human antibody combinations determined by epitope mapping of orthopoxvirus A33/A35 confer therapeutic protection in mice