Research
GPCR-MAPS: high-resolution functional and allosteric mapping of G-protein-coupled receptor activation functions and bias
Nature · By Taylor L. Mighell ·
The Brief
- GPCR-MAPS is a method for scalable functional mapping of G-protein-coupled receptors, published in Nature Structural & Molecular Biology on 11 November 2026.
- The method obtains measurements across multiple phenotypes to map receptor activation functions, allosteric effects and bias.
- The work is presented by Mighell and Lehner, identified by the source as the authors.
Why it matters
GPCRs are major drug targets, and a scalable way to map their activation functions and biased signalling could help researchers characterise how receptors respond to different ligands and mutations.
Who’s affected
- structural biologists and pharmacologists studying G-protein-coupled receptors
- drug discovery researchers working on receptor signalling bias
- #gpcr
- #receptor-pharmacology
- #signal-bias
- #functional-mapping
- #allostery
Nature Structural & Molecular Biology, Published online: 11 November 2026; doi:10.1038/s41594-026-01907-3 Mighell and Lehner present GPCR-MAPS, which enables scalable functional mapping of G-protein-coupled receptors. They obtained measurements across multiple phenotypes of the…
Timeline
GPCR-MAPS published online in Nature Structural & Molecular Biology
nature.com
GPCR-MAPS: high-resolution functional and allosteric mapping of G-protein-coupled receptor activation functions and bias