Research
Glutamine binding and sodium coordination reveal the transport mechanism of y⁺LAT1/CD98hc
Nature · By David Aparicio ·
The Brief
- Cryo-EM, functional and computational studies examine the y⁺LAT1/CD98hc transporter.
- The study describes how the transporter couples sodium binding with substrate recognition, including glutamine.
- The transporter is linked to lysinuric protein intolerance.
Why it matters
The structural details of how this amino acid transporter selects its substrates and uses sodium could inform future work on transporter function and related disease mechanisms.
Who’s affected
- structural biologists and researchers studying membrane transporters
- researchers studying lysinuric protein intolerance
- #cryo-em
- #amino acid transport
- #lysinuric protein intolerance
- #membrane transporters
- #structural biology
Nature Communications, Published online: 14 November 2026; doi:10.1038/s41467-026-79388-7 Here, cryo-EM, functional and computational studies reveal how the lysinuric protein intolerance transporter y⁺LAT1/CD98hc integrates Na⁺ and substrate recognition to mediate selective…
Timeline
Published online in Nature Communications (doi:10.1038/s41467-026-79388-7)
nature.com
Glutamine binding and sodium coordination reveal the transport mechanism of y⁺LAT1/CD98hc