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GLP-1s often contain untested additive combinations, study finds

Medical Xpress ·

GLP-1s often contain untested additive combinations, study finds

The Brief

  • Use of GLP-1 receptor agonist medications has risen sharply in recent years.
  • Many people use compounded GLP-1 products, which combine a GLP-1 with other active substances.
  • Some of the other substances in compounded products are not regulated by the FDA; a new study examined these combinations and reports that they are often untested.

Why it matters

Patients using compounded GLP-1 products may be taking combinations of ingredients that have not been tested together, so their safety and effects are less certain than for approved medicines.

Who’s affected

  • people using or considering compounded GLP-1 products
  • clinicians and pharmacists who prescribe or dispense GLP-1 medications

Use of GLP-1 receptor agonist medications (GLP-1s) has skyrocketed in recent years, and many people are using "compounded" GLP-1 products: medicines that include GLP-1s as well as other active substances, some of which are not regulated by the FDA. A new study found that…

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