Research
Glial progenitor-like state is preferentially co-opted in glioblastoma and sustained by POU3F3
Neuron · By Susana I. Ramos, Mohammad Imran K. Khan, Wan Sze Cheng, Balagopal Pai, Thenzing J. Silva-Hurtado, Jorge Samanamud, Xi Chen, Kristin G. Beaumont, Robert P. Sebra, Raymund L. Yong, Timothy E. Richardson, Amanda Krausert, Lakshmi S.K. Mahadevan, Elena Zaslavsky & Nadejda M. Tsankova ·
The Brief
- Ramos, Khan et al. report a conserved developmental state in glioblastoma that is preferentially co-opted in primary and recurrent tumor cells.
- The state resembles late-gestation glial intermediate progenitor cells (gIPCs).
- The authors identify POU3F3 as a factor that sustains this glial progenitor-like state.
Why it matters
The work links glioblastoma, including recurrent tumors, to a normal developmental cell state and identifies POU3F3 as a candidate that sustains it, which may suggest new therapeutic targets.
Who’s affected
- neuro-oncology researchers
- glioblastoma and cancer biology researchers
- #glioblastoma
- #cancer biology
- #oncofetal
- #neurodevelopment
- #pou3f3
Ramos and Khan et al. assess oncofetal biology in glioblastoma and discover a conserved developmental state preferentially co-opted in primary and recurrent tumor cells, which is reminiscent of late-gestation glial intermediate progenitor cells (gIPCs). They uncover POU3F3 as a…
Timeline
Study published online (Glial progenitor-like state is preferentially co-opted in glioblastoma and sustained by POU3F3)
cell.com
Glial progenitor-like state is preferentially co-opted in glioblastoma and sustained by POU3F3