Research
Gene discovery and pleiotropic architecture of multidimensional pain in a genome-wide association study of >1.2 million individuals
Nature · By Sylvanus Toikumo ·
The Brief
- A meta-analytic genome-wide association study covered more than 1.2 million European-ancestry individuals.
- The study identified 343 independent loci associated with multidimensional pain.
- The article was published online in Nature Neuroscience on 12 November 2026.
Why it matters
The large sample and hundreds of loci give pain researchers a broad genetic basis for studying multidimensional pain, which may help explain why pain differs between people.
Who’s affected
- pain researchers and geneticists
- neuroscientists studying pain pathways
- #pain
- #genetics
- #gwas
- #neuroscience
- #pleiotropy
Nature Neuroscience, Published online: 12 November 2026; doi:10.1038/s41593-026-02455-1 We conducted a meta-analytic genome-wide association study of multidimensional pain in >1.2 million European-ancestry individuals. We identified 343 independent loci, which, alongside findings…
Timeline
Study published online in Nature Neuroscience
nature.com
Gene discovery and pleiotropic architecture of multidimensional pain in a genome-wide association study of >1.2 million individuals